Main Article Content
Abstract
Purpose: This study aims to determine the effect of PEG-7 glyceryl cocoate at concentrations of F1 0.2%, F2 0.4%, and F3 0.6% on the physical stability and cleaning power of micellar water preparations containing mangosteen peel extract. The best formulation was then tested for its antioxidant activity using the DPPH method.
Research Method: This study used a laboratory experimental method. The variations in PEG-7 glyceryl cocoate concentration used in the micellar water extract of mangosteen peel were F1 (0.2%), F2 (0.4%), F3 (0.6%), and negative control F0 (0%). Evaluations were conducted on physical stability tests (organoleptic, pH, homogeneity, and viscosity) and cleaning power. The best micellar water formulation was then tested for antioxidant activity using the DPPH method. The test results were analyzed using a One-Way ANOVA test.
Results and Discussion: The results of testing F3 micellar water, with the highest concentration of PEG-7 glyceryl cocoate, demonstrated that it was the best formula and exhibited the best cleaning ability. The results of the analysis using one-way ANOVA showed a p-value of < 0.05. The antioxidant activity of F3 was determined to have an IC50 of 103.81 μg/ml, which falls within the moderate category.
Implications: The results of this study indicate that PEG-7 glyceryl cocoate at a concentration of 0.6% can be used as a surfactant in micellar water preparations of mangosteen peel extract. Further research is needed to determine the long-term stability of the preparation.
Keywords
Article Details

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References
- Abubakar, A. R., & Haque, M. (2020). Preparation of medicinal plants: Basic extraction and fractionation procedures for experimental purposes. Journal of Pharmacy and Bioallied Sciences, 12(1), 1–10. https://doi.org/10.4103/jpbs.JPBS_175_19
- Aiyuba, D. S., Rakhmatullah, A. N., & Restapaty, R. (2023). Uji Aktivitas Antioksidan Ekstrak Metanol Daun Ramania (Bouea macrophylla Griffith.) Menggunakan Metode DPPH. Jurnal Surya Medika, 9(1), 81–87. https://doi.org/10.33084/jsm.v9i1.5150
- Alves, T. F. R., Morsink, M., Batain, F., Chaud, M. V., Almeida, T., Fernandes, D. A., Silva, C. F., & Souto, E. B. (2020). Synthetic Polymers in Cosmetic Formulations. Cosmetics, 7(75), 1–16.
- Bi, C., Xu, H., Yu, J., Ding, Z., & Liu, Z. (2023). Botanical characteristics, chemical components, biological activity, and potential applications of mangosteen. PeerJ, 11. https://doi.org/10.7717/peerj.15329
- Blaak, J., Grabmann, S., Simon, I., Callaghan, T., & Staib, P. (2023). Five dimensions of cleansing: A holistic view on the facets and importance of skin cleansing. International Journal of Cosmetic Science, 45(5), 557–571. https://doi.org/10.1111/ics.12879
- Depkes RI. (2014). Farmakope Indonesia Edisi V. Jakarta: Departemen Kesehatan Republik Indonesia.
- Depkes RI. (2017). Farmakope Herbal Indonesia Edisi II. Jakarta: Departemen Kesehatan Republik Indonesia.
- Dzakwan, M. (2020). Formulasi Micellar Based Water Ekstrak Bunga Telang. Parapemikir : Jurnal Ilmiah Farmasi, 9(2), 61–67. https://doi.org/10.30591/pjif.v9i2.2043
- Emma Jayanti Besan; Muhammad Nurul Fadel; Nura Ali Dahbul; Gempita Hutami Dameriad; Fendy Prasetyawan. (2024). Uji Aktivitas Antioksidan Ekstrak Dan Fraksi-Fraksi Herba Suruhan (Peperomia pellucida L.) dengan Metode DPPH. Indonesia Jurnal Farmasi, 9(1), 20–25.
- Fadel, M. N., Besan, E. J., Apriliani, F., Djamal, J. M., & Sholekhah, N. (2023). Uji Aktivitas Antioksidan Fraksi n-Heksan, Etil Asetat dan Air Ektrak Etanol Daun Pisang Kepok (Musa paradisiaca L.) dengan Metode DPPH (1, 1 dipheniyl-2 picrylhidrazyl). In Prosiding University Research Colloquium, 1061–1070.
- Fiume, M. M., Bergfeld, W. F., Belsito, D. V., Hill, R. A., Klaassen, C. D., Liebler, D. C., Marks, J. G., Shank, R. C., Slaga, T. J., Snyder, P. W., Gill, L. J., & Heldreth, B. (2020). Safety Assessment of PEGylated Alkyl Glycerides as Used in Cosmetics. International Journal of Toxicology, 39(2_suppl), 26S-58S. https://doi.org/10.1177/1091581820951557
- Hani Pratiwi; Sari Defi Okzelia; Mawar Afiah. (2024). Formulation of Micellar-Based Water from Piper crocatum Leaves Extract Using Various Concentrations of Poloxamer 188. 10(2), 214–233. https://doi.org/10.22487/j24428744.2024.v10.i2.16628
- Hasibuan, L. A., & Mambang, D. E. P. (2022). Uji Efek Analgetik Ekstrak Etanol Daun Tapak Dara (Catharanthus roseus (L) G. Don) Pada Mencit Putih Jantan (Mus Musculus) Dengan Metode Writhing Test. Journal of Health and Medical Science, 1(2), 125–130.
- Hoang, H. T., Moon, J. Y., & Lee, Y. C. (2021). Natural antioxidants from plant extracts in skincare cosmetics: Recent applications, challenges and perspectives. Cosmetics, 8(4), 1–24. https://doi.org/10.3390/cosmetics8040106
- Hussen, N. H. Amin, Abdulla, S. K., Ali, N. M., Ahmed, V. A., Hasan, A. H., & Qadir, E. E. (2025). Role of antioxidants in skin aging and the molecular mechanism of ROS: A comprehensive review. Aspects of Molecular Medicine, 5. https://doi.org/10.1016/j.amolm.2025.100063
- John, O. D., Mouatt, P., Panchal, S. K., & Brown, L. (2021). Rind from purple mangosteen (Garcinia mangostana) attenuates diet‐induced physiological and metabolic changes in obese rats. Nutrients, 13(2), 1–19. https://doi.org/10.3390/nu13020319
- Kazmierczak, E., Magalhães, C. G., & Pereira, R. P. (2023). Antioxidant property of secondary metabolites from Garcinia genus: A short review. Ecletica Quimica, 48(1), 41–54. https://doi.org/10.26850/1678-4618eqj.v48.1.2023.p41-54
- Li, Z. (2020). Modern Mild Skin Cleansing. Journal of Cosmetics, Dermatological Sciences and Applications, 10(02), 85–98. https://doi.org/10.4236/jcdsa.2020.102009
- Maulina, S. N., Zebua, N. F., & Salsabila, D. (2022). Uji Aktivitas Antioksidan Ekstrak Etanol Kulit Buah Manggis (Garcinia mangostana L.) dalam Sediaan Serum Dengan Metode DPPH. Journal of Pharmaceutical And Sciences, 5(2), 372–380. https://doi.org/10.36490/journal-jps.com.v5i2.129
- Michalak, M. (2022). Plant-Derived Antioxidants: Significance in Skin Health and the Ageing Process. International Journal of Molecular Sciences, 23(2). https://doi.org/10.3390/ijms23020585
- Mijaljica, D., Spada, F., & Harrison, I. P. (2022). Skin Cleansing without or with Compromise: Soaps and Syndets. Molecules, 27(6). https://doi.org/10.3390/molecules27062010
- Nabilah, D. A., Nurmay, S., Stiani, Udin, B., & Lutfiyah, F. (2023). Analisis Antioksidan Ekstrak Kulit Buah Manggis (Garcinia mangostana L.) Menggunakan Metode DPPH (2,2 – Diphenyl – 1 – picrilhydrazil). Jurnal Ilmiah Kesehatan Delima, 3(2), 45–51.
- Nugraheni, T. S., Setiawan, I., Putri, A. A., & Wahyu, A. (2024). Tinjauan Artikel : Macam-Macam Metode Pengujian Aktivitas Antioksidan Article Review : Various Methods for Testing Antioxidant Activity. Jurnal Farmasi (Journal of Pharmacy), 13(1), 39–50.
- Nurdianti, L., Hidayat, T., & Bastian, R. (2022). Formulasi dan Evaluasi Sediaan Suppositoria Ekstrak Etanol Kulit Buah Manggis (Garcinia mangostana L.). Prosiding Seminar Nasional Diseminasi Hasil Penelitian Program Studi S1 Farmasi, 2, 113–122.
- Partuti, T., Priyanti, P., Nadyana, H. E., & Daniya, A. A. (2021). Characteristics of mangosteen rind peel-off gel mask with various concentrations. Teknika: Jurnal Sains Dan Teknologi, 17(1), 95. https://doi.org/10.36055/tjst.v17i1.10401
- Puspita, A. S. N., Wrasiati, L. P., & Dewi Anggreni, A. A. M. (2023). The Pengaruh Rasio VCO Wortel (Daucus carota L.) Dan Lemak Kakao (Theobroma cacao L.) Serta Lama Pengadukan Terhadap Karakteristik Sediaan Krim. Jurnal Rekayasa Dan Manajemen Agroindustri, 11(1), 113. https://doi.org/10.24843/jrma.2023.v11.i01.p11
- Rachmadani, A. D., Nurlaila, S. R., & Harismah, K. (2022). Formulasi dan Uji Stabilitas Sediaan Pembersih Wajah (Cleansing oil) Berbahan Dasar Minyak Jarak (Ricinus Communis). Jurnal Farmasi Klinik Dan Sains, 2(1), 104. https://doi.org/10.26753/jfks.v2i1.784
- Raknam, P. S. P. T. A. (2020). Rubber Seed Cleansing Oil Formulation And Its Efficacy Of Makeup Remover. 11(1), 146–155. https://doi.org/10.13040/IJPSR.0975-8232.11(1).146-55
- Saristiana, Y., Wahdi, A., & Prasetyawan, F. (2024). Identifikasi Senyawa Antioksidan Ekstrak Kulit Buah Manggis (Garcinia mangostana L.). Well Being, 9(1), 71–79. https://doi.org/10.51898/wb.v9i1.246
- Tjitrosoepomo, G. (1994). Taksonomi tumbuhan obat-obatan. Gadjah Mada University Press.
- Tran, V. A., Thi Vo, T. T., Nguyen, M. N. T., Duy Dat, N., Doan, V. D., Nguyen, T. Q., Vu, Q. H., Le, V. T., & Tong, T. D. (2021). Novel α -Mangostin Derivatives from Mangosteen (Garcinia mangostana L.) Peel Extract with Antioxidant and Anticancer Potential. Journal of Chemistry, 2021(1), 1–12. https://doi.org/10.1155/2021/9985604
- Wardana, D., Ramadhan, A., Fitri Amne, D. P., & Eddiyanto, E. (2019). Utilization of Glycerol from Used Oil as an Ester Glycerol Surfactant. Indonesian Journal of Chemical Science and Technology (IJCST), 2(2), 111. https://doi.org/10.24114/ijcst.v2i2.13999
- Widowati, W., Ginting, C. N., & Lister, I. N. E. (2020). Anti-aging Effects of Mangosteen Peel Phytochemical Compounds : Antioxidant Inhibition and Molecular Docking Simulation Authors : Extract Activity , and Its Enzyme Ermi Girsang , Annisa Amalia , Satrio Haryo Benowo Wibowo , Hanna Sari Widya Kusuma and Riz. Tropical Life Sciences Research, 31(3), 127–144.
- Wusono, C. N., Hendrawati, T. Y., Ismiyati, Nugrahani, R. A., & Hajir, S. (2023). Pengaruh Penambahan Aloe vera Glycolyc Extract Pada Produk Kosmetik Micellar Water. Prosiding Seminar Nasional Penelitian LPPM UMJ, 1. http://jurnal.umj.ac.id/index.php/semnaslit
- Yayan Rizikiyan, Lela Sulastri, Sulistiorini Indriaty, Khofifah, & Yuniarti Falya. (2022). Formulasi Dan Uji Aktivitas Antioksidan Lotion Ekstrak Etanol Kulit Buah Manggis (Garcinia mangostana L.) Dengan Metode DPPH (2,2-difenyl-1-piksrylhidrazyl). Medical Sains : Jurnal Ilmiah Kefarmasian, 7(2), 147–160. https://doi.org/10.37874/ms.v7i2.330
- Yuvanatemiya, V., Srean, P., Klangbud, W. K., Venkatachalam, K., Wongsa, J., Parametthanuwat, T., & Charoenphun, N. (2022). A Review of the Influence of Various Extraction Techniques and the Biological Effects of the Xanthones from Mangosteen (Garcinia mangostana L.) Pericarps. Molecules, 27(24). https://doi.org/10.3390/molecules27248775
References
Abubakar, A. R., & Haque, M. (2020). Preparation of medicinal plants: Basic extraction and fractionation procedures for experimental purposes. Journal of Pharmacy and Bioallied Sciences, 12(1), 1–10. https://doi.org/10.4103/jpbs.JPBS_175_19
Aiyuba, D. S., Rakhmatullah, A. N., & Restapaty, R. (2023). Uji Aktivitas Antioksidan Ekstrak Metanol Daun Ramania (Bouea macrophylla Griffith.) Menggunakan Metode DPPH. Jurnal Surya Medika, 9(1), 81–87. https://doi.org/10.33084/jsm.v9i1.5150
Alves, T. F. R., Morsink, M., Batain, F., Chaud, M. V., Almeida, T., Fernandes, D. A., Silva, C. F., & Souto, E. B. (2020). Synthetic Polymers in Cosmetic Formulations. Cosmetics, 7(75), 1–16.
Bi, C., Xu, H., Yu, J., Ding, Z., & Liu, Z. (2023). Botanical characteristics, chemical components, biological activity, and potential applications of mangosteen. PeerJ, 11. https://doi.org/10.7717/peerj.15329
Blaak, J., Grabmann, S., Simon, I., Callaghan, T., & Staib, P. (2023). Five dimensions of cleansing: A holistic view on the facets and importance of skin cleansing. International Journal of Cosmetic Science, 45(5), 557–571. https://doi.org/10.1111/ics.12879
Depkes RI. (2014). Farmakope Indonesia Edisi V. Jakarta: Departemen Kesehatan Republik Indonesia.
Depkes RI. (2017). Farmakope Herbal Indonesia Edisi II. Jakarta: Departemen Kesehatan Republik Indonesia.
Dzakwan, M. (2020). Formulasi Micellar Based Water Ekstrak Bunga Telang. Parapemikir : Jurnal Ilmiah Farmasi, 9(2), 61–67. https://doi.org/10.30591/pjif.v9i2.2043
Emma Jayanti Besan; Muhammad Nurul Fadel; Nura Ali Dahbul; Gempita Hutami Dameriad; Fendy Prasetyawan. (2024). Uji Aktivitas Antioksidan Ekstrak Dan Fraksi-Fraksi Herba Suruhan (Peperomia pellucida L.) dengan Metode DPPH. Indonesia Jurnal Farmasi, 9(1), 20–25.
Fadel, M. N., Besan, E. J., Apriliani, F., Djamal, J. M., & Sholekhah, N. (2023). Uji Aktivitas Antioksidan Fraksi n-Heksan, Etil Asetat dan Air Ektrak Etanol Daun Pisang Kepok (Musa paradisiaca L.) dengan Metode DPPH (1, 1 dipheniyl-2 picrylhidrazyl). In Prosiding University Research Colloquium, 1061–1070.
Fiume, M. M., Bergfeld, W. F., Belsito, D. V., Hill, R. A., Klaassen, C. D., Liebler, D. C., Marks, J. G., Shank, R. C., Slaga, T. J., Snyder, P. W., Gill, L. J., & Heldreth, B. (2020). Safety Assessment of PEGylated Alkyl Glycerides as Used in Cosmetics. International Journal of Toxicology, 39(2_suppl), 26S-58S. https://doi.org/10.1177/1091581820951557
Hani Pratiwi; Sari Defi Okzelia; Mawar Afiah. (2024). Formulation of Micellar-Based Water from Piper crocatum Leaves Extract Using Various Concentrations of Poloxamer 188. 10(2), 214–233. https://doi.org/10.22487/j24428744.2024.v10.i2.16628
Hasibuan, L. A., & Mambang, D. E. P. (2022). Uji Efek Analgetik Ekstrak Etanol Daun Tapak Dara (Catharanthus roseus (L) G. Don) Pada Mencit Putih Jantan (Mus Musculus) Dengan Metode Writhing Test. Journal of Health and Medical Science, 1(2), 125–130.
Hoang, H. T., Moon, J. Y., & Lee, Y. C. (2021). Natural antioxidants from plant extracts in skincare cosmetics: Recent applications, challenges and perspectives. Cosmetics, 8(4), 1–24. https://doi.org/10.3390/cosmetics8040106
Hussen, N. H. Amin, Abdulla, S. K., Ali, N. M., Ahmed, V. A., Hasan, A. H., & Qadir, E. E. (2025). Role of antioxidants in skin aging and the molecular mechanism of ROS: A comprehensive review. Aspects of Molecular Medicine, 5. https://doi.org/10.1016/j.amolm.2025.100063
John, O. D., Mouatt, P., Panchal, S. K., & Brown, L. (2021). Rind from purple mangosteen (Garcinia mangostana) attenuates diet‐induced physiological and metabolic changes in obese rats. Nutrients, 13(2), 1–19. https://doi.org/10.3390/nu13020319
Kazmierczak, E., Magalhães, C. G., & Pereira, R. P. (2023). Antioxidant property of secondary metabolites from Garcinia genus: A short review. Ecletica Quimica, 48(1), 41–54. https://doi.org/10.26850/1678-4618eqj.v48.1.2023.p41-54
Li, Z. (2020). Modern Mild Skin Cleansing. Journal of Cosmetics, Dermatological Sciences and Applications, 10(02), 85–98. https://doi.org/10.4236/jcdsa.2020.102009
Maulina, S. N., Zebua, N. F., & Salsabila, D. (2022). Uji Aktivitas Antioksidan Ekstrak Etanol Kulit Buah Manggis (Garcinia mangostana L.) dalam Sediaan Serum Dengan Metode DPPH. Journal of Pharmaceutical And Sciences, 5(2), 372–380. https://doi.org/10.36490/journal-jps.com.v5i2.129
Michalak, M. (2022). Plant-Derived Antioxidants: Significance in Skin Health and the Ageing Process. International Journal of Molecular Sciences, 23(2). https://doi.org/10.3390/ijms23020585
Mijaljica, D., Spada, F., & Harrison, I. P. (2022). Skin Cleansing without or with Compromise: Soaps and Syndets. Molecules, 27(6). https://doi.org/10.3390/molecules27062010
Nabilah, D. A., Nurmay, S., Stiani, Udin, B., & Lutfiyah, F. (2023). Analisis Antioksidan Ekstrak Kulit Buah Manggis (Garcinia mangostana L.) Menggunakan Metode DPPH (2,2 – Diphenyl – 1 – picrilhydrazil). Jurnal Ilmiah Kesehatan Delima, 3(2), 45–51.
Nugraheni, T. S., Setiawan, I., Putri, A. A., & Wahyu, A. (2024). Tinjauan Artikel : Macam-Macam Metode Pengujian Aktivitas Antioksidan Article Review : Various Methods for Testing Antioxidant Activity. Jurnal Farmasi (Journal of Pharmacy), 13(1), 39–50.
Nurdianti, L., Hidayat, T., & Bastian, R. (2022). Formulasi dan Evaluasi Sediaan Suppositoria Ekstrak Etanol Kulit Buah Manggis (Garcinia mangostana L.). Prosiding Seminar Nasional Diseminasi Hasil Penelitian Program Studi S1 Farmasi, 2, 113–122.
Partuti, T., Priyanti, P., Nadyana, H. E., & Daniya, A. A. (2021). Characteristics of mangosteen rind peel-off gel mask with various concentrations. Teknika: Jurnal Sains Dan Teknologi, 17(1), 95. https://doi.org/10.36055/tjst.v17i1.10401
Puspita, A. S. N., Wrasiati, L. P., & Dewi Anggreni, A. A. M. (2023). The Pengaruh Rasio VCO Wortel (Daucus carota L.) Dan Lemak Kakao (Theobroma cacao L.) Serta Lama Pengadukan Terhadap Karakteristik Sediaan Krim. Jurnal Rekayasa Dan Manajemen Agroindustri, 11(1), 113. https://doi.org/10.24843/jrma.2023.v11.i01.p11
Rachmadani, A. D., Nurlaila, S. R., & Harismah, K. (2022). Formulasi dan Uji Stabilitas Sediaan Pembersih Wajah (Cleansing oil) Berbahan Dasar Minyak Jarak (Ricinus Communis). Jurnal Farmasi Klinik Dan Sains, 2(1), 104. https://doi.org/10.26753/jfks.v2i1.784
Raknam, P. S. P. T. A. (2020). Rubber Seed Cleansing Oil Formulation And Its Efficacy Of Makeup Remover. 11(1), 146–155. https://doi.org/10.13040/IJPSR.0975-8232.11(1).146-55
Saristiana, Y., Wahdi, A., & Prasetyawan, F. (2024). Identifikasi Senyawa Antioksidan Ekstrak Kulit Buah Manggis (Garcinia mangostana L.). Well Being, 9(1), 71–79. https://doi.org/10.51898/wb.v9i1.246
Tjitrosoepomo, G. (1994). Taksonomi tumbuhan obat-obatan. Gadjah Mada University Press.
Tran, V. A., Thi Vo, T. T., Nguyen, M. N. T., Duy Dat, N., Doan, V. D., Nguyen, T. Q., Vu, Q. H., Le, V. T., & Tong, T. D. (2021). Novel α -Mangostin Derivatives from Mangosteen (Garcinia mangostana L.) Peel Extract with Antioxidant and Anticancer Potential. Journal of Chemistry, 2021(1), 1–12. https://doi.org/10.1155/2021/9985604
Wardana, D., Ramadhan, A., Fitri Amne, D. P., & Eddiyanto, E. (2019). Utilization of Glycerol from Used Oil as an Ester Glycerol Surfactant. Indonesian Journal of Chemical Science and Technology (IJCST), 2(2), 111. https://doi.org/10.24114/ijcst.v2i2.13999
Widowati, W., Ginting, C. N., & Lister, I. N. E. (2020). Anti-aging Effects of Mangosteen Peel Phytochemical Compounds : Antioxidant Inhibition and Molecular Docking Simulation Authors : Extract Activity , and Its Enzyme Ermi Girsang , Annisa Amalia , Satrio Haryo Benowo Wibowo , Hanna Sari Widya Kusuma and Riz. Tropical Life Sciences Research, 31(3), 127–144.
Wusono, C. N., Hendrawati, T. Y., Ismiyati, Nugrahani, R. A., & Hajir, S. (2023). Pengaruh Penambahan Aloe vera Glycolyc Extract Pada Produk Kosmetik Micellar Water. Prosiding Seminar Nasional Penelitian LPPM UMJ, 1. http://jurnal.umj.ac.id/index.php/semnaslit
Yayan Rizikiyan, Lela Sulastri, Sulistiorini Indriaty, Khofifah, & Yuniarti Falya. (2022). Formulasi Dan Uji Aktivitas Antioksidan Lotion Ekstrak Etanol Kulit Buah Manggis (Garcinia mangostana L.) Dengan Metode DPPH (2,2-difenyl-1-piksrylhidrazyl). Medical Sains : Jurnal Ilmiah Kefarmasian, 7(2), 147–160. https://doi.org/10.37874/ms.v7i2.330
Yuvanatemiya, V., Srean, P., Klangbud, W. K., Venkatachalam, K., Wongsa, J., Parametthanuwat, T., & Charoenphun, N. (2022). A Review of the Influence of Various Extraction Techniques and the Biological Effects of the Xanthones from Mangosteen (Garcinia mangostana L.) Pericarps. Molecules, 27(24). https://doi.org/10.3390/molecules27248775