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Abstract

Purpose: This study aimed to evaluate the use of antituberculosis drugs (OAT) in HIV/AIDS patients with tuberculosis coinfection at X Hospital in Kudus by identifying patient characteristics, patterns of OAT and antiretroviral (ARV) use, and the rationality of OAT therapy using the Gyssens method.


Research Method: This study used a descriptive evaluative design with a retrospective approach based on medical record data. The sample consisted of 41 HIV/AIDS patients with TB coinfection treated at X Hospital in Kudus during November 2024-November 2025, selected using total sampling. Data were analyzed univariately, while therapeutic rationality was assessed using the Gyssens method.


Results and Discussion: Most patients were adults (92.7%) and male (82.9%). The most common OAT regimen was RHZE (4FDC) (70.7%), while the dominant ARV regimen was TLD (95.1%). All OATs were administered orally as tablets, and the duration of therapy was appropriate in all cases. The Gyssens evaluation showed rational OAT use in 95.1% of patients and irrational use in 4.9%, with inappropriate dosage as the main problem.


Implications: These findings indicate that OAT prescribing practices were generally consistent with treatment guidelines, but body-weight-based dose adjustment still requires improvement. Further studies should explore the relationship between rational therapy, adherence, and clinical outcomes in TB-HIV patients.

Keywords

antituberculosis drugs HIV/AIDS tuberculosis coinfection gyssens method rational drug use antiretroviral therapy

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How to Cite
Luthfi, E. L., Setyowati, E., & Rosnarita, I. A. (2026). Evaluation of The Use of Antituberculosis Drugs in Hiv (Aids) Patients at X Hospital in Kudus. Advances in Healthcare Research, 4(1). https://doi.org/10.60079/ahr.v4i1.707
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